...oaches to block inhibitory pathways of the immune system have renewed hopes for the utility of such therapies2. Here we show that genetic deletion of the E3 ubiquitin ligase Cbl-b (casitas B-lineage lymphoma-b) or targeted inactivation of its E3 ligase activity lice1es natural killer (NK) cells to spontaneously reject metastatic tumou1. The TAM tyrosine kinase recepto1 Tyro3, Axl and Mer (also kno...
