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Neurology:体重减轻可能是老年痴呆信号之一

2012/01/08 来源:新浪科技
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研究早就发现,中年体重超标是老年痴呆症的一大危险因素。但美国“网络医学博士网”近日引述《神经病学》杂志刊登美国的一项最新研究称,老人体重减轻可能是早期老年痴呆症的信号之一,甚至会出现在记忆力问题等其他症状之前。

研究早就发现,中年体重超标是老年痴呆症的一大危险因素。但美国“网络医学博士网”近日引述《神经病学》杂志刊登美国的一项最新研究称,老人体重减轻可能是早期老年痴呆症的信号之一,甚至会出现在记忆力问题等其他症状之前。

新研究中,堪萨斯大学老年痴呆症研究中心主任杰弗里·M·伯恩斯博士及其同事调查了506名参试者,有的人没记忆问题,有的存在轻微记忆问题,有的已确诊为老年痴呆症患者。

大脑扫描结果发现,体重减轻、同时存在轻微记忆问题的老人中,85%的人大脑中发现了β-淀粉斑(老年痴呆症的关键特征之一)。而在存在轻微记忆问题的体重超标老人中,这个比率仅为48%。伯恩斯博士表示,研究结果表明,老年痴呆症有非常早期的身体变化信号——体重减轻。“老年痴呆症只是大脑疾病”的传统理念也许并不科学。


Alzheimer disease biomarkers are associated with body mass index

E.D. Vidoni, R.A. Townley,  R.A. Honea, DPhil, J.M. Burns, 

Objective: Both low and high body mass index (BMI) has been associated with cognitive impairment and dementia risk, including Alzheimer disease (AD). We examined the relationship of BMI with potential underlying biological substrates for cognitive impairment.

Methods: We analyzed cross-sectional data from participants enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI) with PET imaging using Pittsburgh Compound B (PiB, n = 101) or CSF analyses (n = 405) for β-amyloid peptide (Aβ) and total tau. We assessed the relationship of CSF biomarkers and global PiB uptake with BMI using linear regression controlling for age and sex. We also assessed BMI differences between those who were and were not considered biomarker positive. Finally, we assessed BMI change over 2 years in relationship to AD biomarkers.

Results: No dementia, mild cognitive impairment (MCI), and AD groups were not different in age, education, or BMI. In the overall sample, CSF Aβ (β = 0.181, p < 0.001), tau (β = −0.179, p < 0.001), tau/Aβ ratio (β = −0.180, p < 0.001), and global PiB uptake (β = −0.272, p = 0.005) were associated with BMI, with markers of increased AD burden associated with lower BMI. Fewer overweight individuals had biomarker levels indicative of pathophysiology (p < 0.01). These relationships were strongest in the MCI and no dementia groups.

Conclusions: The presence and burden of in vivo biomarkers of cerebral amyloid and tau are associated with lower BMI in cognitively normal and MCI individuals. This supports previous findings of systemic change in the earliest phases of the disease. Further, MCI in those who are overweight may be more likely to result from heterogeneous pathophysiology.

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