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Neurology:维生素、Ω-3脂肪酸或有助延缓老年脑萎缩

2011/12/30 来源:新华网
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美国的一项新研究显示,如果老年人体内维生素C、D、E、B族维生素和Ω-3脂肪酸水平较高,出现这种疾病的风险可能会降低。

老年脑萎缩是老人中常见的慢性脑病。伴随衰老过程,老年人脑体积缩小、重量减轻、脑细胞数量减少,引起记忆力、判断力和思考能力退化。美国的一项新研究显示,如果老年人体内维生素C、D、E、B族维生素和Ω-3脂肪酸水平较高,出现这种疾病的风险可能会降低。

研究人员还发现,维生素和脂肪酸水平高的老年人在记忆及思维测试中得分较高,而体内反式脂肪较高者在测试中得分较低,脑萎缩风险也较高。Ω-3脂肪酸和维生素D在鱼类中含量较高,而B族维生素以及具有抗氧化功能的维生素C、E在水果和蔬菜中含量较高。

研究人员对104名平均年龄为87岁的老人进行了血测,确定了每人血液中营养成分的水平,然后让他们参加记忆和思维测试。这些老人基本没有与记忆和思维问题相关的风险因子。研究人员发现,维生素和脂肪酸水平较高者的脑容量最多超出水平较低者37%,在记忆和思维测试中的得分最多超出后者17%。

研究报告已经发表在美国神经病学学会出版的《神经病学》杂志上。参与研究的俄勒冈卫生和科学大学助理教授吉恩·鲍曼表示,尽管研究结果还有待进一步确认,但通过调节饮食来延缓脑萎缩的想法“足以令人激动”。


Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging

G.L. Bowman, MPH, L.C. Silbert, MCR, D. Howieson, H.H. Dodge, M.G. Traber, B. Frei, J.A. Kaye, J. Shannon, MPH and J.F. Quinn

Objective: To examine the cross-sectional relationship between nutrient status and psychometric and imaging indices of brain health in dementia-free elders.

Methods: Thirty plasma biomarkers of diet were assayed in the Oregon Brain Aging Study cohort (n = 104). Principal component analysis constructed nutrient biomarker patterns (NBPs) and regression models assessed the relationship of these with cognitive and MRI outcomes.

Results: Mean age was 87 ± 10 years and 62% of subjects were female. Two NBPs associated with more favorable cognitive and MRI measures: one high in plasma vitamins B (B1, B2, B6, folate, and B12), C, D, and E, and another high in plasma marine ω-3 fatty acids. A third pattern characterized by high trans fat was associated with less favorable cognitive function and less total cerebral brain volume. Depression attenuated the relationship between the marine ω-3 pattern and white matter hyperintensity volume.

Conclusion: Distinct nutrient biomarker patterns detected in plasma are interpretable and account for a significant degree of variance in both cognitive function and brain volume. Objective and multivariate approaches to the study of nutrition in brain health warrant further study. These findings should be confirmed in a separate population.

文献链接http://www.neurology.org/content/early/2011/12/28/WNL.0b013e3182436598.abstract?sid=45ad0338-9962-4735-83b5-273003d58a70

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