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过度吸烟增加精神分裂症自杀风险

2011/12/28 来源:焦虑世界
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一项最新发表在《Psychiatry Research》杂志上的研究指出,与不吸烟的精神分裂症患者相比,过度吸烟的精神分裂症患者的自杀风险明显增加。

一项最新发表在《Psychiatry Research》杂志上的研究指出,与不吸烟的精神分裂症患者相比,过度吸烟的精神分裂症患者的自杀风险明显增加。

Yu-Chen Kao(Songshan Armed Forces General Hospital, Taipei, Taiwan)和他的同事们说道:“过度吸烟可能是精神分裂症患者(尤其是女性患者)自杀风险最为重要的临床标志。”

这项研究发现是非常重要的,原因是精神分裂症患者中吸烟者的比例高于普通人群。

本研究纳入95例精神分裂症(DSM-IV诊断标准)门诊患者,进行为期1年的随访调查,对受试者过去和目前的吸烟情况进行记录。此外,对受试者的临床病程、社会功能、自杀风险、精神病理学、抗抑郁药物诱导的副作用、冲动、抑郁、焦虑和悲观主义进行评估。

研究者们发现,65%的患者每天的吸烟量为最少20支/天,且符合尼古丁依赖的诊断标准。男性患者首次吸烟的年龄(17.6 vs 20.7)和首次发病(23.9 vs 25.9)年龄早于女性患者。与非吸烟者相比,吸烟患者的自杀企图的患病率较高(65% vs 39%),与此同时,吸烟患者的住院次数、抗精神病药治疗期间的副作用、精神病理学、冲动性、抑郁和焦虑风险亦较高。多元回归分析显示,烟草使用、抑郁症状、焦虑症状以及冲动与自杀风险高度相关。

研究者们总结:今后的研究应关注这类人群的人口统计学特征和临床影响因素,以便于更好地理解吸烟在精神分裂症患者总自杀率中的作用。


参考文献

Cigarette smoking in outpatients with chronic schizophrenia in Taiwan: Relationships to socio-demographic and clinical characteristics

Kao YC, Liu YP, Cheng TH, Chou MK.

In individuals with schizophrenia, the prevalence of cigarette smoking is significantly higher than that of the general population; this appears to be associated with specific psychosocial and clinical characteristics. Indeed, some evidence suggests an increased risk of suicide among smokers with schizophrenia. The purpose of this study was to examine the characteristics of smokers with schizophrenia in Taiwan. In this cross-sectional study, 95 outpatients with DSM-IV diagnosis of schizophrenia were recruited and independently interviewed for nicotine dependency with tobacco use. The effects of cigarette smoking on the various measures, especially suicidality, were investigated. The results revealed that smokers with schizophrenia had higher rates of hospitalization, lifetime suicide attempts, antipsychotic treatment side effects, psychopathology, impulsivity, depression, anxiety, and suicidal risk than non-smokers with schizophrenia. When separate analyses were conducted in male and female patients, depressive symptoms were significant predictors of suicidality among males, whereas heavy smoking, anxious symptoms, and hopelessness were significant predictors among females. From this study, we may gain insights into the role of cigarette smoking in patients of schizophrenia in Taiwan. Furthermore, cigarette smoking may influence aspects of suicidality in schizophrenia.

文献链接:http://www.psy-journal.com/article/S0165-1781(11)00382-9/fulltext

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