贝康招聘
伯豪生物转化医学服务平台
威斯腾促销

AGE:衰老速度与血糖浓度有关

2011/12/20 来源:新华网
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导读
爱吃甜食不仅使人肥胖,还会导致皮肤过早衰老,让你看起来比实际年龄更老。但会老多少?

爱吃甜食不仅使人肥胖,还会导致皮肤过早衰老,让你看起来比实际年龄更老。但会老多少?

 

荷兰莱顿大学黛安娜·范海姆斯特领导的研究小组根据569名健康的志愿者饭后的血糖浓度将他们分成低、中、高三组。研究人员还对3 3名血糖水平更高的糖尿病患者进行了研究。

研究人员要求60名独立的评估者看志愿者的照片,并对每名志愿者看上去的年龄进行评价。结果显示,血糖水平高的人看起来更老,即使实际年龄、吸烟以及晒日光浴等影响外貌的其他因素也被考虑在内。

血糖水平最低的组和糖尿病组之间的“外表年龄”差距最大,达到1年7个月,这两个组的平均外表年龄分别是59.6岁和61.2岁。但即使在没有糖尿病的志愿者中,血糖水平最低和最高的组之间也有1岁的差距。总之,每升血液中葡萄糖浓度每增加0.18克,外表年龄增加5个月。

共同负责该项目的戴维·冈恩说:“身体内的状况都写在脸上。”


High serum glucose levels are associated with a higher perceived age

Noordam R, Gunn DA, Tomlin CC, Maier AB, Mooijaart SP, Slagboom PE, Westendorp RG, de Craen AJ, van Heemst D; On behalf of the Leiden Longevity Study Group.

Estimating perceived age by facial photographs is a good estimate of health in elderly populations. Previously, we showed that familial longevity is marked by a more beneficial glucose metabolism already at middle age. As glucose is also related to skin aging, this study aimed to investigate the association between glucose metabolism and perceived age. Perceived age was assessed using facial photographs and non-fasted glucose and insulin were measured in 602 subjects from the Leiden Longevity Study. Non-diabetic subjects (n = 569) were divided in three strata according to their glucose levels, and diabetic subjects (n = 33; as a proxy of long-term hyperglycemic exposure) were included as a fourth stratum. Considered confounding factors were gender, chronological age, current smoking, body mass index, photo-damage score, and insulin levels. Perceived age was increased from 59.6 years (SE = 0.3) in the first stratum to 61.2 years (SE = 0.6) in diabetic subjects (p for trend = 0.002). In non-diabetic subjects only, perceived age was increased from 59.6 years (SE = 0.3) in the first stratum to 60.6 years (SE = 0.3) in the third stratum (p for trend = 0.009). Continuously, perceived age increased 0.40 years (SE = 0.14, p = 0.006) per 1 mmol/L increase in glucose level in non-diabetic subjects. The present study demonstrates that, also among non-diabetic subjects, higher glucose levels are associated with a higher perceived age. Future research should be focused on elucidating possible mechanisms linking glucose levels to perceived age.

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