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他汀类药物或可用来治疗流感

2011/12/18 来源:《传染病期刊》
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美国研究人员在美国《传染病期刊》上公布的一项研究结果显示,用于降低胆固醇水平的他汀类药物或许也有助于降低流感重症患者的死亡率。

他汀类药物可用来治疗流感

他汀类药物是降脂常用药,常见的有阿伐他汀、辛伐他汀、普伐他汀、卢伐他汀和弗伐他汀等。

美国研究人员12月14日在美国《传染病期刊》(Journal of Infectious Diseases)上公布的一项研究结果显示,用于降低胆固醇水平的他汀类药物或许也有助于降低流感重症患者的死亡率。

美国俄勒冈州公共卫生局的研究人员分析了2007年至2008年间因严重流感而住院的美国10个州的3000多名患者的数据。他们发现,剔除年龄、是否患心脏病、肺部或肾脏疾病、是否接受过抗病毒药物达菲治疗等因素后,住院期间仍服用他汀类药物的患者的死亡率比未服用者低41%。

研究人员表示,他汀类药物将来有可能用于流感的治疗,但目前不应将其加入流感住院患者的标准疗法。这项研究还存在局限性,例如服用他汀类药物的流感患者是否比未服用的患者更健康等情况不得而知,需要进一步研究证实他汀类药物的益处。

由于具有抗感染功能,他汀类药物近年来引起了病毒学家的关注。曾有研究表明,他汀类药物可以降低流感患者体内的炎症,避免其免疫系统对病毒反应过度。


他汀类药物或有助降低流感死亡率 参考文献

Association Between Use of Statins and Mortality Among Patients Hospitalized With Laboratory-Confirmed Influenza Virus Infections: A Multistate Study

Meredith L. Vandermeer, Ann R. Thomas, Laurie Kamimoto, Arthur Reingold, Ken Gershman, James Meek, Monica M. Farley, Patricia Ryan, Ruth Lynfield, Joan Baumbach, William Schaffner, Nancy Bennett and Shelley Zansky

Background Statins may have anti-inflammatory and immunomodulatory effects that could reduce the risk of mortality from influenza virus infections.

Methods The Centers for Disease Control and Prevention’s Emerging Infections Program conducts active surveillance for persons hospitalized with laboratory-confirmed influenza in 59 counties in 10 states. We analyzed data for hospitalized adults during the 2007–2008 influenza season to evaluate the association between receiving statins and influenza-related death.

Results We identified 3043 patients hospitalized with laboratory-confirmed influenza, of whom 1013 (33.3%) received statins and 151 (5.0%) died within 30 days of their influenza test. Patients who received statins were more likely to be older, male, and white; to suffer from cardiovascular, metabolic, renal, and chronic lung disease; and to have been vaccinated against influenza that season. In a multivariable logistic regression model, administration of statins prior to or during hospitalization was associated with a protective odds of death (adjusted odds ratio, 0.59 [95% confidence interval, .38–.92]) when adjusting for age; race; cardiovascular, lung, and renal disease; influenza vaccination; and antiviral administration.

Conclusions Statin use may be associated with reduced mortality in patients hospitalized with influenza.

文献链接:http://jid.oxfordjournals.org/content/early/2011/12/12/infdis.jir695.abstract?sid=f60f8d83-c65f-4b91-bbac-89072126dd55

 

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