PNAS:恶性肿瘤“天生就坏”?
2018/05/17
侵入性肿瘤是“误入歧途”还是“天生就坏”?这个问题是癌症早期发现和治疗的一个关键。5月14日,《PNAS》期刊上一篇文章揭示了良性肿瘤、恶性肿瘤在发生之初的差异,表明一些恶性肿瘤的坏“与生俱来”。


图片来源:Pixabay

得益于筛查技术的快速发展,许多小的“癌前”肿瘤被检测到,这有利于及时干预,降低晚期癌症的死亡率,但是同时也面临着过度诊断的难题。所以,在早期区分良性肿瘤和恶性肿瘤很重要。

在最新的研究中,来自于杜克大学、南加州大学的科学家们以结直肠癌为病例,发现侵袭性癌症属于“先天就坏”的类型。


doi.org/10.1073/pnas.1716552115

研究团队招募了19位结直肠肿瘤患者,利用数学多尺度模型(mathematical multiscale models)与多区域测序(multiregional sequencing)寻找良性肿瘤、恶性肿瘤在生长初期的差异。结果在多数侵入性肿瘤样本(9/15)中发现了早期细胞异常运动的特征,这一特征是肿瘤扩散所必需的。而他们在4份良性肿瘤样本中并没有发现明显的细胞异常运动迹象。

文章作者Marc D. Ryser表示,肿瘤的许多关键特征早已深刻在起源细胞的基因组中。因此,他们推测,侵袭性肿瘤最初就具备扩散的能力,而不是伴随时间而发展出来的。也就是说,它们的坏“与生俱来”。

研究人员强调,这一研究规模较小,依然需要更大的样本量来验证这一结论。但是这一发现是建立区分良性、恶性肿瘤检测方案的重要一步。未来,这种早期的细胞异常运动有望应用于癌症的诊断中。

责编:艾曼

参考资料:

Deadly cancers show early, detectable differences from benign tumors

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