“坚果抗癌”新证据!每周吃两份坚果,改善结肠癌生存
2018/03/16
“坚果抗癌”又有新证据了——来自耶鲁癌症中心的一项大型研究证实,与不吃坚果的患者相比,经常食用坚果的III期结肠癌患者的癌症复发风险和死亡率显著更低。


图片来源:Journal of Clinical Oncology(DOI: 10.1200/JCO.2017.75.5413)

2月28日,这项研究成果以“Nut Consumption and Survival in Patients With Stage III Colon Cancer: Results From CALGB 89803 (Alliance)”为题发表在Journal of Clinical Oncology杂志上。

该研究跟踪了一项临床试验中的826名参与者(在他们接受手术和化疗治疗后),中位随访期为6.5年。结果显示,每周至少吃2份坚果的人无病生存期提高了42%,总生存期提高了57%。

细分研究表明,吃树坚果而不是花生(ate tree nuts rather than peanuts)的参与者无病生存期提高了46%。其中,树坚果包括杏仁、核桃、榛子、腰果和山核桃等。


图片来源:16sucai

论文的第一作者Temidayo Fadelu博士说:“我们的发现与其他一些观察性研究相一致。先前的这些研究表明,健康的行为(如增加身体活动、保持健康的体重、减少糖和加糖饮料的摄入)能够改善结肠癌的结果;而我们的结果强调了饮食和生活方式对结肠癌患者生存的重要性。”

事实上,通常,由于担心高脂肪含量(一盎司约24颗杏仁含约200卡路里,包括14克脂肪),病人可能不会吃坚果。论文的通讯作者Charles S. Fuchs博士说:“有人问我,是否增加坚果摄入会导致肥胖,从而引发更差的结果?有趣的是,在我们的研究,以及其他科学文献中,定期吃坚果的人倾向于更瘦。

值得一提的是,除了坚果,在相同的患者群体中,Fuchs博士及其同事还发现了“喝咖啡”与“结肠癌复发和死亡率降低”之间的关联。

“当我为患者提供关于生活方式选择的建议时,首先我会说的是,避免肥胖,经常锻炼,以及远离高碳水化合物饮食;然后才会谈到咖啡和坚果之类的东西。总的来说,我们正致力于将用于定义新药的、同样严谨的科学,用于理解结肠癌患者人群的饮食和生活方式。” Fuchs博士总结道。

参考资料:

Nut consumption may aid colon cancer survival

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  • Nut Consumption and Survival in Patients With Stage III Colon Cancer: Results From CALGB 89803 (Alliance)

    Purpose Observational studies have reported increased colon cancer recurrence and mortality in patients with states of hyperinsulinemia, including type 2 diabetes, obesity, sedentary lifestyle, and high glycemic load diet. Nut intake has been associated with a lower risk of type 2 diabetes, metabolic syndrome, and insulin resistance. However, the effect of nut intake on colon cancer recurrence and survival is not known. Patients and Methods We conducted a prospective, observational study of 826 eligible patients with stage III colon cancer who reported dietary intake on food frequency questionnaires while enrolled onto a randomized adjuvant chemotherapy trial. Using Cox proportional hazards regression, we assessed associations of nut intake with cancer recurrence and mortality. Results After a median follow-up of 6.5 years, compared with patients who abstained from nuts, individuals who consumed two or more servings of nuts per week experienced an adjusted hazard ratio (HR) for disease-free survival of 0.58 (95% CI, 0.37 to 0.92; Ptrend = .03) and an HR for overall survival of 0.43 (95% CI, 0.25 to 0.74; Ptrend = .01). In subgroup analysis, the apparent benefit was confined to tree nut intake (HR for disease-free survival, 0.54; 95% CI, 0.34 to 0.85; Ptrend = .04; and HR for overall survival, 0.47; 95% CI, 0.27 to 0.82; Ptrend = .04). The association of total nut intake with improved outcomes was maintained across other known or suspected risk factors for cancer recurrence and mortality. Conclusion Diets with a higher consumption of nuts may be associated with a significantly reduced incidence of cancer recurrence and death in patients with stage III colon cancer.

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