Nature子刊:这种抗焦虑药物,有望逆转长期酗酒的伤害
2018/02/17
“喝酒伤身”,特别是大脑。已有研究表明,过量酒精会损伤神经元再生。近期,Nature子刊《Scientific Reports》揭示,一种用于治疗焦虑的药物,能够修复小鼠大脑中因为过量饮酒而造成的神经损伤。


图片来源:网络

带来这一惊喜结果的药物是tandospirone(坦度螺酮),一种在中国、日本上市的抗焦虑性药物,可选择性地作用于大脑血清素受体(5-HT1A受体)。

来自于昆士兰科技大学(QUT)的科学家们以成年小鼠为模型发现,每日服用tandospirone(连续2周)能够修复持续15周过度饮酒对神经再生的影响。


图片来源:Scientific Reports(doi:10.1038/s41598-018-20504-z)

过去已有研究证实,坦度螺酮可以促进大脑神经元的再生。现在,团队负责人、QUT健康健康与生物医学创新研究所的神经科学家Selena Bartlett带领团队第一次证明,坦度螺酮可以逆转因为酒精而造成的神经损伤。

而且,该药物能够有效控制与戒酒有关的焦虑行为,显著减少酒精摄取量。这些结果表明,5-HT1A受体在饮酒相关的情绪失调、神经损伤中发挥着关键作用,同时,5-HT1A受体激动剂有望成为治疗酒精滥用的潜在药物。需要注意的是,这些研究目前只在动物身上进行,未来,还需要投入更多的研究。

当然,更重要的是,还是尽量避免过量饮酒。正值新春佳节,小伙伴们是否在奔赴各种宴席的路上呢?小编温馨提醒,饮酒适量,不可贪杯喔!

参考资料:

Drug shown to reverse brain deficits caused by alcohol

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  • 5-HT1A receptor-dependent modulation of emotional and neurogenic deficits elicited by prolonged consumption of alcohol

    Repeated episodes of binge-like alcohol consumption produce anxiety, depression and various deleterious effects including alterations in neurogenesis. While the involvement of the serotonin receptor 1 A (5-HT1A) in the regulation of anxiety-like behavior and neurogenesis is well documented, its contribution to alcohol withdrawal-induced anxiety and alcohol-induced deficits in neurogenesis is less documented. Using the Drinking-In-the-Dark (DID) paradigm to model chronic long-term (12 weeks) binge-like voluntary alcohol consumption in mice, we show that the selective partial activation of 5-HT1A receptors by tandospirone (3 mg/kg) prevents alcohol withdrawal-induced anxiety in a battery of behavioral tests (marble burying, elevated-plus-maze, open-field), which is accompanied by a robust decrease in binge-like ethanol intake (1 and 3 mg/kg). Furthermore, using triple immunolabelling of proliferation and neuronal differentiation markers, we show that long-term DID elicits profound deficits in neurogenesis and neuronal fate specification in the dorsal hippocampus that are entirely reversed by a 2-week chronic treatment with the 5-HT1A partial agonist tandospirone (3 mg/kg/day). Together, our results confirm previous observations that 5-HT1A receptors play a pivotal role in alcohol drinking behavior and the associated emotional and neurogenic impairments, and suggest that 5-HT1A partial agonists represent a promising treatment strategy for alcohol abuse.

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