重磅!陈子江团队生殖研究成果再次荣登《新英格兰医学杂志》
近日,山东大学生殖医学研究中心陈子江教授团队的一项多中心随机对照临床研究成果“排卵正常的不孕症患者移植冻胚与鲜胚的比较”在《新英格兰医学杂志》(IF: 72.4)以原创论文发表 (N Engl J Med 2018,378(2):126-136)。据悉,这是该团队在该刊发表的第2篇原创性研究论文。


本文转载自“山东大学齐鲁医学院”。

该研究由山东大学附属生殖医院、上海交通大学附属仁济医院等全国20家医院的生殖医学中心共同完成,是针对目前不孕症治疗“试管婴儿”技术在临床上应用中存在的争议和困惑,而进行的科学设计和严谨的多中心大样本随机对照试验。

本研究结果提示,在有排卵的不孕症患者中实施体外受精与胚胎移植(试管婴儿)治疗中,“与鲜胚移植比较,全胚冷冻-冻胚移植的活产率及孕产期并发症无明显差异”,为不孕症的临床诊疗实践及个体化诊疗提供了进一步的高质量的循证医学证据,并为临床辅助生殖技术(试管婴儿技术)“全胚冷冻-冻胚移植策略”的患者利益最大化、治疗有效性、长期安全性评价以及个体化应用价值提供了科学依据,有望对今后的辅助生殖技术相关临床实践、临床治疗指南的修定和实施起到积极作用。

近年来,“全胚冷冻策略”是生殖医学领域广泛关注的热点问题。陈子江教授团队2016年《新英格兰医学杂志》发表的文章,在国际上首次证实在以排卵障碍为主要特征的多囊卵巢综合征(PCOS)不孕症患者中,与新鲜胚胎移植相比,全胚冷冻-冷冻胚胎移植可明显提高活产率,降低主要并发症。获国际领域同行专家的高度评价,2017年10月美国生殖医学学会年会特邀陈子江教授就该成果在主会场做30分钟专题报告。(作者:高亚文)

所有文章仅代表作者观点,不代表本站立场。如若转载请联系原作者。
查看更多
  • Transfer of Fresh versus Frozen Embryos in Ovulatory Women

    BACKGROUND Elective frozen-embryo transfer has been shown to result in a higher live-birth rate than fresh-embryo transfer among anovulatory women with the polycystic ovary syndrome. It is uncertain whether frozen-embryo transfer increases live-birth rates among ovulatory women with infertility. METHODS In this multicenter, randomized trial, we randomly assigned 2157 women who were undergoing their first in vitro fertilization cycle to undergo either fresh-embryo transfer or embryo cryopreservation followed by frozen-embryo transfer. Up to two cleavage-stage embryos were transferred in each participant. The primary outcome was a live birth after the first embryo transfer. RESULTS The live-birth rate did not differ significantly between the frozen-embryo group and the fresh-embryo group (48.7% and 50.2%, respectively; relative risk, 0.97; 95% confidence interval [CI], 0.89 to 1.06; P=0.50). There were also no significant between-group differences in the rates of implantation, clinical pregnancy, overall pregnancy loss, and ongoing pregnancy. Frozen-embryo transfer resulted in a significantly lower risk of the ovarian hyperstimulation syndrome than fresh-embryo transfer (0.6% vs. 2.0%; relative risk, 0.32; 95% CI, 0.14 to 0.74; P=0.005). The risks of obstetrical and neonatal complications and other adverse outcomes did not differ significantly between the two groups. CONCLUSIONS The live-birth rate did not differ significantly between fresh-embryo transfer and frozen-embryo transfer among ovulatory women with infertility, but frozen-embryo transfer resulted in a lower risk of the ovarian hyperstimulation syndrome.

    展开 收起
发表评论 我在frontend\modules\comment\widgets\views\文件夹下面 test