有了答案!为什么运动可减缓帕金森?
2017/12/28
之前的研究已证实,跑步可减缓帕金森病的进程,但这背后的分子原因一直是个谜。最近,科学家们或许给出了答案——运动可以阻止脑细胞中α-突触核蛋白的积聚。


这项研究由科罗拉多大学安舒茨医学院副教授Wenbo Zhou博士和临床药理学与毒理学部主任Curt Freed博士所领导,研究结果发表在《PLOS ONE》杂志上。

“我们的研究结果表明,运动可以通过阻止大脑中α-突触核蛋白异常积聚,来减缓帕金森病的发展”,Freed博士说。

作为一种慢性、渐进性的运动障碍,帕金森症病一直被认为是由大脑中负责运动控制的大脑区域中神经细胞或神经元的死亡而发生。科研人员推测,α-突触核蛋白异常积聚是导致神经细胞死亡的原因之一,也被认为帕金森症的一个生物标志。

在这项研究中,研究人员为观察小鼠在运动中的神经保护作用,在12个月大的小鼠笼子里装了滚轮,开始了为期3个月的观察。Zhou说:“我们观察到,实验组比对照组的小鼠运动和认知功能要好得多。

研究人员发现,锻炼增加了实验组小鼠大脑和肌肉中的DJ-1 关键基因的表达,随之而来的是,肌肉和血液中的DJ-1蛋白浓度的增加。而对照组,即DJ-1基因敲除的小鼠,运动能力则严重下降。这表明,DJ-1蛋白是正常运动所必需的。据了解,那些出生带有DJ-1罕见基因突变的人类,在年轻的时候就会出现很严重的帕金森病。

Freed表示,这项动物实验对人类有非常实际的意义,因为它说明了,运动可以触及帕金森病问题的核心。

就目前而言,虽然还没有对帕金森病的动物模型进行长期锻炼的观察研究。但长期的锻炼确实可以预防与年龄相关的神经退行性疾病的发生,所以让我们动起来吧!

参考资料

Researchers shed light on why exercise slows progression of Parkinson's disease

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  • Running wheel exercise reduces α-synuclein aggregation and improves motor and cognitive function in a transgenic mouse model of Parkinson's disease

    Exercise has been recommended to improve motor function in Parkinson patients, but its value in altering progression of disease is unknown. In this study, we examined the neuroprotective effects of running wheel exercise in mice. In adult wild-type mice, one week of running wheel activity led to significantly increased DJ-1 protein concentrations in muscle and plasma. In DJ-1 knockout mice, running wheel performance was much slower and Rotarod performance was reduced, suggesting that DJ-1 protein is required for normal motor activity. To see if exercise can prevent abnormal protein deposition and behavioral decline in transgenic animals expressing a mutant human form of α-synuclein in all neurons, we set up running wheels in the cages of pre-symptomatic animals at 12 months old. Activity was monitored for a 3-month period. After 3 months, motor and cognitive performance on the Rotarod and Morris Water Maze were significantly better in running animals compared to control transgenic animals with locked running wheels. Biochemical analysis revealed that running mice had significantly higher DJ-1, Hsp70 and BDNF concentrations and had significantly less α-synuclein aggregation in brain compared to control mice. By contrast, plasma concentrations of α-synuclein were significantly higher in exercising mice compared to control mice. Our results suggest that exercise may slow the progression of Parkinson’s disease by preventing abnormal protein aggregation in brain.

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