Science证实:细菌会伴随肿瘤的转移而转移!
2017/11/28
哈佛大学的科学家们最新发现:结肠癌中的常见细菌,会伴随着肿瘤的转移而转移。而且当采取抗生素对抗这些细菌时,小鼠体内的肿瘤扩散、转移会得到控制。他们推测:这类细菌与肿瘤成功转移有很大的关联性。


细菌与人类共生,这已经不是什么秘密。现在,越来越来多的疾病被证实与微生物有关,包括肿瘤。

2017年9月,《Science》曾发表一篇文章揭示:胰腺癌中存在细菌。更糟糕的是,这些细菌会“消化”化疗药物,影响治疗效果,从而导致肿瘤细胞对药物产生耐药性。在这之前已有实验室发现细菌与多种肿瘤细胞“共存”的现象,这让科学家们开始怀疑:细菌是否是肿瘤形成的原因?

11月23日,同样是Science上的文章再一次指明,结肠癌中也存在细菌,而且,最常见菌种——具核梭杆菌(Fusobacterium nucleatum)会随着肿瘤的转移在患者体内传播。

来自于哈佛大学的研究团队采集了结肠癌患者的结肠、肝脏样本,分析发现:当结肠处的肿瘤组织携带细菌时,肝脏处的肿瘤样本也同样存在相同类型的细菌。反过来,当结肠肿瘤未携带细菌时,转移至肝脏组织中的肿瘤细胞也同样没有细菌潜伏。

这一发现让科学家们很意外。他们将患者的肿瘤组织植入健康小鼠体内。结果显示,只有携带细菌的肿瘤才能够在小鼠体内生长、扩增。随后,研究人员对这批小鼠进行抗生素治疗(消灭具核梭杆菌),发现小鼠体内的肿瘤生长减缓了。

综合这些结果,研究团队认为,当肿瘤转移时,细菌也会跟着转移。他们推测,细菌有助于肿瘤在新部位“落地生根”。当然,还需要很多的研究来明确细菌是否真的在肿瘤发展中发挥了作用。

参考资料:

Study suggests colon cancer cells carry bacteria with them when they metastasize

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  • Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer

    Colorectal cancers comprise a complex mixture of malignant cells, non-transformed cells and microorganisms. Fusobacterium nucleatum is among the most prevalent bacterial species in colorectal cancer tissues. Here we show that colonization of human colorectal cancers with Fusobacterium and its associated microbiome, including Bacteroides, Selenomonas and Prevotella species, is maintained in distal metastases, demonstrating microbiome stability between paired primary-metastatic tumors. In situ hybridization analysis revealed that Fusobacterium is predominantly associated with cancer cells in the metastatic lesions. Mouse xenografts of human primary colorectal adenocarcinomas were found to retain viable Fusobacterium and its associated microbiome through successive passages. Treatment of mice bearing a colon cancer xenograft with the antibiotic metronidazole reduced Fusobacterium load, cancer cell proliferation and overall tumor growth. These observations argue for further investigation of antimicrobial interventions as a potential treatment for patients with Fusobacterium-associated colorectal cancer.

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