贴膘不怕!肉桂能帮你燃烧脂肪
2017/11/24
肉桂是一种日常饮食中常用的调味品,近日,它又因其他作用被大家所关注——密歇根大学生命科学研究所(the University of Michigan Life Sciences Institute,LSI)的一项研究发现,肉桂有助于脂肪燃烧。


图片来源: CC0 Public Domain

在几乎所有的中国家庭里,肉桂都是炖肉、炒菜主要的调味品,在西方,人们更是用肉桂打成粉末加入咖啡、奶味中调味。由于含有特殊芳香的植物,肉桂还可以制作比较特殊的香料。

此前,科学家已发现,肉桂醛是一种赋予肉桂独特风味的有机化合物,能够保护小鼠免受肥胖和高血糖的困扰,但这种背后的机制尚不完全清楚。

LSI的研究助理教授Jun Wu想进一步弄清楚肉桂醛的作用,并确定它对人类是否也有保护作用。Wu和她的同事在这项研究中对志愿者的脂肪细胞进行了测试,志愿者涵括了不同年龄、种族和体重指数。

研究人员注意到,当用肉桂醛处理细胞后,几种增强脂质代谢的基因和酶的表达增加。他们还发现细胞的Ucp1和Fgf21(参与产热的重要代谢调节蛋白)的增加。

研究指出,肉桂醛直接作用于脂肪细胞,促进机体燃烧脂肪,产生热量,从而可以改善代谢健康。研究结果发表在最新一期的《新陈代谢》杂志上。

脂肪细胞通常以脂质的形式储存能量。这种长期储存对我们祖先是有益的,因为他们很少能接触到高脂肪的食物,因此更需要存储脂肪。在缺乏食物的时候,这些脂肪可以将存储的能量转化为热量。

然而,随着现代肥胖症的日益增多,能量过剩已成为一个问题。Wu等研究人员一直在寻找让脂肪燃烧的过程重新开始的方法。

Wu表示,“肉桂已经成为我们几千年饮食的一部分,如果它能有助于预防肥胖,那么说服病人坚持以肉桂为基础的治疗,而不是传统的药物治疗方案可能会更容易。”

当然Wu也提醒道,还需要进一步的研究来确定,如何最好地利用肉桂醛的代谢益处,避免不必要的副作用。

参考资料

Cinnamon turns up the heat on fat cells

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  • Cinnamaldehyde induces fat cell-autonomous thermogenesis and metabolic reprogramming

    Objective Cinnamaldehyde (CA) is a food compound that has previously been observed to be protective against obesity and hyperglycemia in mouse models. In this study, we aimed to elucidate the mechanisms behind this protective effect by assessing the cell-autonomous response of primary adipocytes to CA treatment. Methods Primary murine adipocytes were treated with CA and thermogenic and metabolic responses were assessed after both acute and chronic treatments. Human adipose stem cells were differentiated and treated with CA to assess whether the CA-mediated signaling is conserved in humans. Results CA significantly activated PKA signaling, increased expression levels of thermogenic genes and induced phosphorylation of HSL and PLIN1 in murine primary adipocytes. Inhibition of PKA or p38 MAPK enzymatic activity markedly inhibited the CA-induced thermogenic response. In addition, chronic CA treatment regulates metabolic reprogramming, which was partially diminished in FGF21KO adipocytes. Importantly, both acute and chronic effects of CA were observed in human adipose stem cells isolated from multiple donors of different ethnicities and ages and with a variety of body mass indexes (BMI). Conclusions CA activates thermogenic and metabolic responses in mouse and human primary subcutaneous adipocytes in a cell-autonomous manner, giving a mechanistic explanation for the anti-obesity effects of CA observed previously and further supporting its potential metabolic benefits on humans. Given the wide usage of cinnamon in the food industry, the notion that this popular food additive, instead of a drug, may activate thermogenesis, could ultimately lead to therapeutic strategies against obesity that are much better adhered to by participants.

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