BGI最新自然通讯论文:女性生殖系统中与健康相关的微生物群
Nature自然科研 · 2017/10/20
《自然-通讯》发表的一篇文章The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases报告女性生殖系统(从阴道到输卵管)中存在特定微生物群。这些发现挑战了人类胚胎发育是在无菌环境下开展的这一传统观点。


本文转载自“Nature自然科研”。

《自然-通讯》发表的一篇文章The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases报告女性生殖系统(从阴道到输卵管)中存在特定微生物群。这些发现挑战了人类胚胎发育是在无菌环境下开展的这一传统观点。该研究还表明这些微生物群落中的变异与某些子宫病症相关,因此它们或许能用作某些疾病的生物标记。

已知阴道中有大量微生物,但是在无感染状态下,女性上生殖系统中是否存在情况明了的微生物群一直不确定。深圳华大基因研究院的贾慧珏和同事分析了110位处在生育年龄的中国女性的生殖系统中的微生物。他们采集了6个区域的样本:阴道的下三分之一段、后穹隆、宫颈管粘液、子宫内膜、输卵管和子宫直肠窝的腹膜液。


女性生殖系统中各部位的微生物组成。Chen et al.

与此前报告一致,作者发现乳杆菌(Lactobacillus)大量存在于下生殖系统(阴道和穹窿)。越接近上生殖系统,乳杆菌的数量越少,并被其他种类的细菌取代,如假单胞菌(Pseudomonas)。作者成功培养了上生殖系统样本中的细菌,证明活细菌存在于这些区域。最后,研究者发现微生物群中的变异与月经周期阶段存在联系,也与一些病症(如子宫肌瘤、子宫腺肌症和子宫内膜异位导致的不孕)存在关联。


生殖系统不同区域5种微生物群类型。Chen et al.

这些发现证明活细菌存在于女性上生殖系统。他们还指出通过分析宫颈粘液的微生物群,或许可以判断子宫及腹膜腔的健康状况。有必要开展针对更大且前瞻性群组的进一步研究,来验证宫颈微生物群分析用作阴道-子宫病症的生物标记的可能性。

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  • The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases

    Reports on bacteria detected in maternal fluids during pregnancy are typically associated with adverse consequences, and whether the female reproductive tract harbours distinct microbial communities beyond the vagina has been a matter of debate. Here we systematically sample the microbiota within the female reproductive tract in 110 women of reproductive age, and examine the nature of colonisation by 16S rRNA gene amplicon sequencing and cultivation. We find distinct microbial communities in cervical canal, uterus, fallopian tubes and peritoneal fluid, differing from that of the vagina. The results reflect a microbiota continuum along the female reproductive tract, indicative of a non-sterile environment. We also identify microbial taxa and potential functions that correlate with the menstrual cycle or are over-represented in subjects with adenomyosis or infertility due to endometriosis. The study provides insight into the nature of the vagino-uterine microbiome, and suggests that surveying the vaginal or cervical microbiota might be useful for detection of common diseases in the upper reproductive tract.

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