他汀类药物预防阿尔兹海默症?服用2年降低15%的患病率
2016/12/15
他汀类药物能够预防阿尔兹海默症?近期,《JAMA Neurology》期刊最新刊出一篇学术文章揭示,他汀类药物能够对大脑产生积极的影响,连续服用2年能够显著降低老年人患老年痴呆症的概率。


他汀类药物是降脂类降胆固醇、高脂血症领域的典型药物,其减缓动脉粥硬化的功效奠定了其在心血管疾病治疗中的重要地位。

来自于南加州大学的研究团队近期,发现除了心血管疾病,他汀类药物还有望应用于预防阿尔兹海默症。他们耗时7年(从2006年至2013年),对40万名美国老年人(65岁以上)进行调研分析。结果显示,他汀类药物能够对大脑产生积极的影响,女性服用这一廉价药物能够降低15%的患病率,男性能够降低12%。

Julie Zissimopoulos教授带领团队分析了调研对象是否服用他汀类药物、服用规律以及阿尔兹海默症患病等数据。总体而言,他们发现,每年会有1.72%的女性和1.32%的男性被确诊为阿尔兹海默症患者。但是,他汀类药物却鞥能够显著降低这一风险,且随着服药时间的延长,患病风险会进一步下降。

研究人员推测,胆固醇可能参与了淀粉样蛋白病斑的形成过程,而他汀类药物能够清理胆固醇,这有利于血液流向大脑,从而有助于抵制神经细胞的死亡。

他们发现,不同类型的他汀类药物对不同性别、种族的人有着不同的治疗效果,例如辛伐他汀(Simvastatin)会降低白人、西班牙裔和黑人女性以及白人、西班牙裔男性患痴呆症的风险。但是,对于黑人男性而言,任何类型的他汀类药物在预防痴呆风险上都没有显著差异。

Julie Zissimopoulos表示:“尽管经历了多年的研究,科学家们仍未研发出能够延缓甚至于逆转老年痴呆的药物。现在,这一最新数据意味着我们或许已经触摸到一个有效治疗手段,他汀类药物可以作为候选药物,用于降低阿尔兹海默症的风险。”

阿尔兹海默症协会研究主任Doug Brown博士评价这一最新研究表示:“”如此庞大的数据足以表明他汀类药物与老年痴呆症的关联性。但是,现有的数据并没有提供直接的证据,表明他汀类药物确实能够影响老年痴呆风险,这一结论仍然需要临床试验证实。

参考资料:

Could statins be the miracle cure for Alzheimer's? Taking the tablets for just 2 years reduces the risk by up to 15%

查看更多
  • Sex and Race Differences in the Association Between Statin Use and the Incidence of Alzheimer Disease

    Importance To our knowledge, no effective treatments exist for Alzheimer disease, and new molecules are years away. However, several drugs prescribed for other conditions have been associated with reducing its risk. Objective To analyze the association between statin exposure and Alzheimer disease incidence among Medicare beneficiaries. Design, Setting, and Participants We examined the medical and pharmacy claims of a 20% sample of Medicare beneficiaries from 2006 to 2013 and compared rates of Alzheimer disease diagnosis for 399 979 statin users 65 years of age or older with high or low exposure to statins and with drug molecules for black, Hispanic, and non-Hispanic white people, and men and women of Asian, Native American, or unkown race/ethnicity who are referred to as “other.” Main Outcomes and Measures The main outcome was incident diagnosis of Alzheimer disease based on the International Classification of Diseases, Ninth Revision, Clinical Modification. We used Cox proportional hazard models to analyze the association between statin exposure and Alzheimer disease diagnosis for different sexes, races and ethnicities, and statin molecules. Results The 399 979 study participants included 7794 (1.95%) black men, 24 484 (6.12%) black women, 11 200 (2.80%) Hispanic men, 21 458 (5.36%) Hispanic women, 115 059 (28.77%) white men, and 195 181 (48.80%) white women. High exposure to statins was associated with a lower risk of Alzheimer disease diagnosis for women (hazard ratio [HR], 0.85; 95% CI, 0.82-0.89; P<.001) and men (HR, 0.88; 95% CI, 0.83-0.93; P<.001). Simvastatin was associated with lower Alzheimer disease risk for white women (HR, 0.86; 95% CI, 0.81-0.92; P<.001), white men (HR, 0.90; 95% CI, 0.82-0.99; P=.02), Hispanic women (HR, 0.82; 95% CI, 0.68-0.99; P=.04), Hispanic men (HR, 0.67; 95% CI, 0.50-0.91; P=.01), and black women (HR, 0.78; 95% CI, 0.66-0.93; P=.005). Atorvastatin was associated with a reduced risk of incident Alzheimer disease diagnosis for white women(HR, 0.84, 95% CI, 0.78-0.89), black women (HR, .081, 95% CI, 0.67-0.98), and Hispanic men (HR, 0.61, 95% CI, 0.42-0.89) and women (HR, 0.76, 95% CI, 0.60-0.97). Pravastatin and rosuvastatin were associated with reduced Alzheimer disease risk for white women only (HR, 0.82, 95% CI, 0.70-0.95 and HR, 0.81, 95% CI, 0.67-0.98, respectively). High statin exposure was not associated with a statistically significant lower Alzheimer disease risk among black men. Conclusions and Relevance The reduction in Alzheimer disease risk varied across statin molecules, sex, and race/ethnicity. Clinical trials that include racial and ethnic groups need to confirm these findings. Because statins may affect Alzheimer disease risk, physicians should consider which statin is prescribed to each patient.

    展开 收起
发表评论 我在frontend\modules\comment\widgets\views\文件夹下面 test