首次证实!母亲BMI会影响婴儿端粒长度
2016/10/24
来自比利时哈塞尔特大学(University Hasselt)的研究人员发现,母亲孕前较高的BMI与新生儿较短的端粒长度有关。母亲的BMI每增加1点(one-point),婴儿的端粒会缩短约50个碱基对。研究人员表示,这相当于成人在1.1-1.6年内端粒碱基对正常丢失的长度。


10月18日,发表在BMC Medicine上的一项研究首次报道称,母亲身体质量指数(Body Mass Index, BMI)与新生儿端粒长度有强大的关联。

端粒是染色体末端的一种结构,对维持人类基因组的稳定至关重要。端粒的长度与一个细胞“一生”能分裂的次数直接相关。更长的端粒会使细胞分裂的次数更多。随着细胞的衰老,端粒会逐渐分解和收缩,最终导致细胞死亡。端粒长度是生物学年龄的一种标志物。先前的研究表明,成人的端粒长度与年龄相关性疾病相关,如心血管疾病、2型糖尿病,但科学家们目前对新生儿端粒的研究依然有限。

来自比利时哈塞尔特大学(University Hasselt)的研究人员发现,母亲孕前较高的BMI与新生儿较短的端粒长度有关。这项研究共调查了743位母亲(年龄在17-44岁之间)和她们的新生儿。为了测量平均端粒长度,研究人员分娩后立即获取了脐带血。

先前的研究表明,人类在成人期每年通常会丢失约32.2-45.5个端粒碱基对。这一研究小组发现,母亲的BMI每增加1点(one-point),婴儿的端粒会缩短约50个碱基对。研究人员表示,这相当于成人在1.1-1.6年内端粒碱基对正常丢失的长度。

该研究的通讯作者Tim Nawrot教授说:“与母亲BMI正常的新生儿相比,肥胖母亲的新生儿在分子水平上显得更老化(older)。因为缩短的端粒长度意味着他们的细胞寿命更短。因此,女性在生育年龄保持健康的BMI可能会促进后代在分子水平上的长寿。”

Nawrot教授还表示,尽管先前有荟萃分析表明,成人BMI与端粒长度有关,但在这一研究之前,没有证据证明孕前BMI与新生儿端粒长度的关联。“我们的研究结果再次证明了母亲高水平的BMI会影响胚胎‘编程’,这可能会导致胎儿发育改变以及后期疾病的发生。”

论文的第一作者Dries Martens说:“我们排除了许多其它可能与端粒长度相关的潜在因素,包括婴儿出生时父母的年龄、社会经济阶层、种族、母亲的吸烟状况以及新生儿的性别和出生体重。”不过,研究人员也表示,因为先前的研究已经描述了父亲体重对新生儿的表观遗传影响,因此,他们的研究可能会受到父亲BMI信息不足的限制。

参考资料

Medicalxpress:Mother's BMI may affect the biological age of newborn babies

BMC Medicine:Maternal pre-pregnancy body mass index and newborn telomere length

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  • Maternal pre-pregnancy body mass index and newborn telomere length

    Background Newborn telomere length sets telomere length for later life. At birth, telomere length is highly variable among newborns and the environmental factors during in utero life for this observation remain largely unidentified. Obesity during pregnancy might reflect an adverse nutritional status affecting pregnancy and offspring outcomes, but the association of maternal pre-pregnancy body mass index (BMI) with newborn telomere length, as a mechanism of maternal obesity, on the next generation has not been addressed. Methods Average relative telomere lengths were measured in cord blood (n = 743) and placental tissue (n = 702) samples using a quantitative real-time PCR method from newborns from the ENVIRONAGE birth cohort in Belgium. By using univariate and multivariable adjusted linear regression models we addressed the associations between pre-pregnancy BMI and cord blood and placental telomere lengths. Results Maternal age was 29.1 years (range, 17–44) and mean (SD) pre-pregnancy BMI was 24.1 (4.1) kg/m2. Decline in newborn telomere length occurred in parallel with higher maternal pre-pregnancy BMI. Independent of maternal and paternal age at birth, maternal education, gestational age, newborn gender, ethnicity, birthweight, maternal smoking status, parity, cesarean section, and pregnancy complications, each kg/m2 increase in pre-pregnancy BMI was associated with a −0.50 % (95 % CI, −0.83 to −0.17 %; P = 0.003) shorter cord blood telomere length and a −0.66 % (95 % CI, −1.06 to −0.25 %; P = 0.002) shorter placental telomere length. Conclusions Maternal pre-pregnancy BMI is associated with shorter newborn telomere lengths as reflected by cord blood and placental telomeres. These findings support the benefits of a pre-pregnancy healthy weight for promoting molecular longevity from early life onwards.

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