细菌与癌症又扯上关系啦,乳腺癌或与菌群失调有关!
2016/08/05
近日,梅奥诊所的一个研究团队发表于8月3日的Scientific Reports上的一项研究表明,他们在无菌培养的乳腺组织中发现,女性乳腺癌与正常乳腺组织中的细菌存在差异。该发现提示菌群失调可能与乳腺癌存在关联。

近日,梅奥诊所的一个研究团队在无菌培养的乳腺组织中发现,女性乳腺癌与正常乳腺组织中的细菌存在差异,这项研究发表于8月3日的Scientific Reports上。

乳腺癌是女性最常见的恶性肿瘤之一,占女性恶性肿瘤的30%。是女性癌症中的主要死因。虽然目前对乳腺癌建立了风险评估,但是现如今的疾病预测模型仍然不能较好地识别单独个体的风险因素。

该研究小组在无菌条件下分别采集了33位病人的乳腺组织、乳腺皮肤组织、皮肤试子和口腔试子的样本,发现这几种样本的微生物组有明显区别。此外,正常乳腺组织与乳腺癌组织中的微生物组也存在明显差异。乳腺癌组织中的梭菌属、奇异菌属、葡糖醋杆菌、噬氢菌属的丰度更高。研究人员认为固有菌群失调可能与乳腺癌的发生发展有关。

乳腺由上皮细胞、基质、黏膜免疫系统组成一个复杂的微环境。微生物组是定居于人体内特殊微环境内的微生物及病毒集合。近年来,越来越多的研究都发现微环境中细菌等微生物与人体健康密切相关,在身体许多部位(包括胃、结肠、肝脏、肺、皮肤)的肿瘤发展的过程中都牵涉到微生物组的差异。有很多证据都表明,乳腺微生物组的改变与癌症的发展以及癌症的侵袭力有关,这意味着消除有害微生物,恢复正常微生物群可能逆转该过程。

研究人员说,尽管现在仍然不清楚微生物群落的改变——比如致病菌株的出现或是有益菌的缺失是否会促进乳腺癌的发展。但是研究人员认为该发现可以刺激更进一步的研究来确认乳腺癌发展的潜在因素及基于微生物的预防治疗措施。

备注:本文参考自MedicalXpress网站,原标题:“Researchers identify breast microbiome/bacterial differences between healthy and cancerous tissue

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