你会不会得慢性疲劳综合征,写在了你的肠道菌群里
2016/07/03
多年来,医生一直被慢性疲劳综合征所困扰。由于缺乏相关知识,有些人甚至认为该疾病可能是心理作用所致。如今,研究人员首次在肠道菌群和血液微生物中找到了该疾病的生物标志物,推翻了传统观念。


多年来,医生一直被慢性疲劳综合征所困扰。由于缺乏相关知识,有些人甚至认为该疾病可能是心理作用所致。如今,研究人员首次在肠道菌群和血液微生物中找到了该疾病的生物标志物,并于6月23日发表在《Microbiome》杂志上。研究人员在文中描述了如何通过粪便和血液来正确诊断慢性疲劳综合征,为该疾病提供了非侵入性的诊断方法,推动了对该疾病的进一步了解。

慢性疲劳综合征是由于各种疾病引起的一种疲劳,且不同于生理性疲劳。多种疾病会出现自觉疲劳、无力等明显的先驱症状,诸如病毒性肝炎、肺结核、糖尿病、心肌梗死、贫血、血液病和癌症等都可使患者感到莫名其妙的疲劳,这种疲劳与体力、脑力、心理性疲劳性质完全不同。慢性疲劳综合征包括休息后仍感疲劳、肌肉关节疼痛、偏头痛、肠胃不适等。

已有研究证实,免疫系统过度活跃对慢性疲劳综合征起一定的作用。目前医生用于检测慢性疲劳综合征手段为心肺运动试验——让患者骑自行车直到疲惫不堪,如果在次日再重复该试验,慢性疲劳综合征患者通常不能重复首日的动作。研究人员说,“这种现象在慢性疲劳综合征患者身上很普遍,健康的人,甚至是具有心脏病的人,第二天均能重复该运动,而慢性疲劳综合征患者却不能。”

在这项研究中,研究人员对48名慢性疲劳综合征确诊患者和39名健康志愿者的粪便和血液样本进行分析,并进行了微生物DNA测序,以确定不同类型的细菌。结果发现,与健康人相比,慢性疲劳综合征患者细菌多样性明显降低,且能抗炎的细菌种类明显减少,此外研究人员在血液中发现了炎症的特殊标志物,这些标志物似乎是因为肠道问题流入血液中,血液中的细菌会引发免疫反应,这可能会导致疾病恶化。

本文资深作者Maureen Hanson教授,“我们的工作表明慢性疲劳综合征患者体内的肠道菌群是异常的,这可能导致胃肠炎等症状,该研究结果推翻了过去关于心理导致慢性疲劳综合征的观点。”本文的合作作者,分子生物学、分子遗传学和微生物学副教授Ruth Ley表示,“在未来,我们可以看到该研究可作为慢性疲劳综合征非侵入性诊断的补充,但如果我们能更好的了解这些肠道菌群和患者之间的关系,或许可以通过改变饮食来缓解疾病症状,如使用益生元和益生菌来帮助治疗疾病。”

然而,研究人员并没有证据来区分肠道菌群的改变是慢性综合征的病因还是结果。在未来,该研究团队将进一步研究以寻找肠道内病毒和真菌的迹象,以探讨它们是否与该疾病有关。

相关链接:

Indicator of chronic fatigue syndrome found in gut bacteria

查看更多
  • Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome

    Background Gastrointestinal disturbances are among symptoms commonly reported by individuals diagnosed with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). However, whether ME/CFS is associated with an altered microbiome has remained uncertain. Here, we profiled gut microbial diversity by sequencing 16S ribosomal ribonucleic acid (rRNA) genes from stool as well as inflammatory markers from serum for cases (n = 48) and controls (n = 39). We also examined a set of inflammatory markers in blood: C-reactive protein (CRP), intestinal fatty acid-binding protein (I-FABP), lipopolysaccharide (LPS), LPS-binding protein (LBP), and soluble CD14 (sCD14). Results We observed elevated levels of some blood markers for microbial translocation in ME/CFS patients; levels of LPS, LBP, and sCD14 were elevated in ME/CFS subjects. Levels of LBP correlated with LPS and sCD14 and LPS levels correlated with sCD14. Through deep sequencing of bacterial rRNA markers, we identified differences between the gut microbiomes of healthy individuals and patients with ME/CFS. We observed that bacterial diversity was decreased in the ME/CFS specimens compared to controls, in particular, a reduction in the relative abundance and diversity of members belonging to the Firmicutes phylum. In the patient cohort, we find less diversity as well as increases in specific species often reported to be pro-inflammatory species and reduction in species frequently described as anti-inflammatory. Using a machine learning approach trained on the data obtained from 16S rRNA and inflammatory markers, individuals were classified correctly as ME/CFS with a cross-validation accuracy of 82.93 %. Conclusions Our results indicate dysbiosis of the gut microbiota in this disease and further suggest an increased incidence of microbial translocation, which may play a role in inflammatory symptoms in ME/CFS.

    展开 收起
发表评论 我在frontend\modules\comment\widgets\views\文件夹下面 test