Plos One:阿司匹林或可降低癌症患者死亡率及转移率
医脉通 · 2016/04/22
近期发表在 PLOS ONE 上的研究考察了癌症治疗中低剂量阿司匹林的作用。研究人员回顾了47项相关研究的数据,结果显示结直肠癌、乳腺癌和前列腺癌的治疗过程中服用低剂量阿司匹林的患者,死亡率降低了15-20%,转移发生率也有所降低。


近期发表在 PLOS ONE 上的研究考察了癌症治疗中低剂量阿司匹林的作用。研究人员回顾了47项相关研究的数据,结果显示结直肠癌、乳腺癌和前列腺癌的治疗过程中服用低剂量阿司匹林的患者,死亡率降低了15-20%,转移发生率也有所降低。

一项最新研究显示,接受癌症治疗的患者服用低剂量阿司匹林能够增加高达20%的生存率,并有助于防止癌症转移。

这项研究来自于 Cardiff 大学医学院教授 Peter Elwood 博士团队。研究人员通过对已发表的研究进行系统性审查发现,患者在癌症治疗方案中加入低剂量阿司匹林显著降低了死亡率和癌症转移率(研究的平均随访时间超过5年)。

“越来越多的证据显示服用阿司匹林显著降低了一些癌症的发生,然而尚不明确阿司匹林在癌症治疗中是否具有类似作用。因此我们对所有已发表的研究进行了系统性调查研究”,Elwood 介绍道。

研究团队回顾了所有已发表的数据,包括5项随机试验和42项观察性研究,涉及了结直肠癌、乳腺癌和前列腺癌领域。

Elwood 教授表示:“基于目前所有可获得的证据,我们的研究显示肠癌、乳腺癌或前列腺癌患者在治疗方案中加入低剂量阿司匹林,与死亡率降低15-20%相关,同时也与转移率降低相关。

“来自其它癌种的6项研究结果也提示存在类似的降低,但是由于患者数量过少,不能得出令人信服的结论。大约20%患者携带 PIK3CA 突变,或许能够解释阿司匹林降低结肠癌死亡率的原因。

“一直以来,服用阿司匹林都存在潜在的消化道出血的顾虑。这也是我们专门考察已存在的出血证据的原因。我们给所有研究作者都去了信,希望获得进一步的数据。目前报告的研究中,没有报告出现严重的或致命的出血。”

作为这项研究的结论,研究团队强调了需要随机对照试验以明确这些证据,以支持在癌症治疗中额外加入低剂量阿司匹林。“现在迫切需要有更多的研究细节支持我们的结论,包括在不那么常见的癌症领域的证据。我们鼓励癌症患者确诊时与医生交流我们的研究结果,从而进行知情决策,以确定是否需要在治疗方案中加入低剂量阿司匹林”, Elwood 教授补充道。

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