Nat Commun:ROBO2基因——婴儿说话的基础
2014/09/23
Nature Communications于9月16日在线发表的一项研究报告:一个与早期语言获取相关的新基因ROBO2已在婴儿身上被识别出。这项发现对人类在语言发展和探索与语言相关的疾病(如“诵读困难症”)中所涉及的通道有更好认识。

幼儿一般在出生后10-15个月,开始第一次说话,随后他们说话的词汇量和语法复杂性之后会迅速增加。

过去有研究对24个月大(此时的宝宝一般采用双单词的组合来说话)的双胞胎所做的研究表明,这种获得的词汇是可遗传的。

最近,Beate St Pourcain与同事利用年龄在15个月到30个月之间的1万多名婴儿的语言能力数据来探究词汇量得分与遗传差异之间的可能联系。

研究过程中,他们在基因组中识别出一个特定区域,该区域与发育早期单个词语的获取显著相关,但在后期当双单词组合形成后就不是这样了。

这一新识别出的区域在一个被称为ROBO2的基因附近,位于3号染色体的一个特定部分内,该基因编码在神经过程中起关键作用的一种蛋白,ROBO2基因被发现跟“诵读困难症”和与语言相关的疾病有关。

所有文章仅代表作者观点,不代表本站立场。如若转载请联系原作者。
查看更多
  • Common variation near ​ROBO2 is associated with expressive vocabulary in infancy

    Twin studies suggest that expressive vocabulary at ~24 months is modestly heritable. However, the genes influencing this early linguistic phenotype are unknown. Here we conduct a genome-wide screen and follow-up study of expressive vocabulary in toddlers of European descent from up to four studies of the EArly Genetics and Lifecourse Epidemiology consortium, analysing an early (15–18 months, ‘one-word stage’, NTotal=8,889) and a later (24–30 months, ‘two-word stage’, NTotal=10,819) phase of language acquisition. For the early phase, one single-nucleotide polymorphism (rs7642482) at 3p12.3 near ​ROBO2, encoding a conserved axon-binding receptor, reaches the genome-wide significance level (P=1.3 × 10−8) in the combined sample. This association links language-related common genetic variation in the general population to a potential autism susceptibility locus and a linkage region for dyslexia, speech-sound disorder and reading. The contribution of common genetic influences is, although modest, supported by genome-wide complex trait analysis (meta-GCTA h215–18-months=0.13, meta-GCTA h224–30-months=0.14) and in concordance with additional twin analysis (5,733 pairs of European descent, h224-months=0.20).

    展开 收起
发表评论 我在frontend\modules\comment\widgets\views\文件夹下面 test