PLoS One:氙气可以删除大脑部分记忆
凤凰科技 · 2014/09/01
据《每日科学》网站报道,麦克莱恩医院研究人员报道最新的科研成果表明,氙气或有可能治疗创伤后应激障碍(PTSD)和其他疾病,而此前,氙气被广泛应用于麻醉和诊断成像。相关研究发表在最新一期《公共科学图书馆·综合》(PLoS One)杂志上。


据《每日科学》网站报道,麦克莱恩医院研究人员报道最新的科研成果表明,氙气或有可能治疗创伤后应激障碍(PTSD)和其他疾病,而此前,氙气被广泛应用于麻醉和诊断成像。

哈佛医学院精神病学助理教授、麦克莱恩医院助理心理学家爱德华·G·海洛尼(Edward G. Meloni)表示:“在研究中,我们发现氙气有减少创伤性事件记忆的能力。这是一个激动人心的突破,因为这有可能成为一种新的治疗创伤后应激障碍的疗法。”

这项研究发表在最新一期《公共科学图书馆·综合》(PLoS One)中。梅洛尼和麦克莱恩医院转化成像实验室主管马克·J·考夫曼(Marc J. Kaufman)博士一起研究了低浓度氙气是否会干扰“重新整合(reconsolidation)”过程——重新激活记忆,变得容易修改。梅洛尼解释道:”从之前的研究中我们知道,每一次情感回忆被唤起时,大脑实际上会把它当做新记忆进行恢复。根据这些情况,我们决定是否测试,是否可以在恐惧记忆被再次激活后,通过立即引入氙气,从而调整该过程。“

研究人员利用了一种恐惧状态下的PTSD动物模型,训练老鼠害怕环境因素,同时配以简单的足底电击。然后,老鼠被再次放置在相同的环境因素中,以唤醒恐惧记忆,测量它们的冰冻反馈来度量恐惧程度。

梅洛尼博士提到:“我们发现,暴露在氙气中可以阻断NMDA受体参与大脑记忆形成,最高可显着减少两周的记忆,就好像害怕的动物不再记得这些。”

梅洛尼指出,氙气一类气体的固有属性是比较理想治疗素材。因为氙气可以快速进出大脑,准确介入大脑唤起回忆的时间,并能够精确控制用量。

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