Am J Clin Nutr:维生素D或并不会阻断心脏病和中风的发生
生物谷 · 2014/09/01
此前研究中研究人员发现,维生素D水平较低的个体更有可能患心血管疾病。然而最近来自东安格利亚大学的研究人员表明,服用维生素D片并不能避免心脏病和中风的发生,虽然二者间存在一些偶然关联。相关研究刊登于国际杂志Am J Clin Nutr上。


近日,来自东安格利亚大学的研究人员通过研究表明,服用维生素D片并不能避免心脏病和中风的发生,相关研究刊登于国际杂志Am J Clin Nutr上。

近来有研究揭示维生素D水平和患多发性硬化症、糖尿病、精神分离症等病症发病数量增加直接相关;此前研究中研究人员发现,维生素D水平较低的个体更有可能患心血管疾病,而本文研究则发现维生素D的补充并不会降低个体患心血管疾病的风险,然而其却可以保护老年个体抵御心脏衰竭。

文章中,研究人员对60岁以上的5000名老年个体进行实验研究,给予一部分参与者一定的维生素D补充剂,其余则给予安慰剂,研究人员对这些参与者进行长达5年的研究,对参与者的心血管事件及致死率进行监测,与此同时研究人员还结合了21项其它的维生素D摄入和心血管疾病相关的研究数据(涵盖13000多人的研究)进行综合分析。

研究者John Ford博士表示,维生素D不仅是一种激素还是一种营养物质,当人们晒太阳时候就可以在机体中产生。我们都知道维生素D具有多种功能,而且研究者推测有可能缺失维生素D会引发个体的心脏疾病及中风风险升高。一些观察性研究也揭示了心血管疾病病人的机体维生素D的循环浓度或许更低,但是这项研究中研究者却发现其两者之间属于一种偶然性关系。

然而有些研究则发现,因心力衰竭死亡的风险或许在服用维生素D补充剂的人群中较低,研究者最后表示,未来还需要更为深入的研究来揭示是否维生素D的补充对人体有益。

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  • Cardiovascular disease and vitamin D supplementation: trial analysis, systematic review, and meta-analysis

    Background: Low 25-hydroxyvitamin D status has been associated with increased cardiovascular events in epidemiologic studies. Objective: We assessed whether vitamin D supplementation reduces cardiac failure, myocardial infarction (MI), and stroke through an analysis of the Randomised Evaluation of Calcium Or vitamin D (RECORD) randomized controlled trial (RCT), a systematic review, and a meta-analysis. Design: Two analyses were undertaken. The first analysis was a trial analysis. The RECORD was a factorial RCT that compared vitamin D3 (800 IU/d), calcium (1000 mg/d), vitamin D plus calcium, and a placebo. Cardiovascular events were collected throughout the trial and 3-y posttrial follow-up. Data were analyzed by using Cox regression. The second analysis was a systematic review. MEDLINE, EMBASE, CENTRAL, conference abstracts, and ongoing trials were searched for RCTs that evaluated vitamin D from 1980 to 2013. RCTs with ≥1 y of follow-up and participants mean or median age ≥60 y were included. Meta-analyses were based on a Bayesian fixed-effects model by using a complementary log-log link function to account for varying lengths of follow-up. Results: In the trial analysis, we showed that, for the 5292 participants in the RECORD trial, HRs (95% CIs) for vitamin D compared with no vitamin D for cardiac failure, MI, and stroke were 0.75 (0.58, 0.97), 0.97 (0.75,1.26), and 1.06 (0.8, 1.32), respectively. Twenty-one studies met the inclusion criteria for the systematic review (n = 13,033). Estimated HRs (credible intervals) for vitamin D compared with the placebo or control for on-study events for cardiac failure, MI, and stroke were 0.82 (0.58, 1.15), 0.96 ( 0.83, 1.10), and 1.07 (0.91, 1.29), respectively. Conclusion: Vitamin D supplementation might protect against cardiac failure in older people but does not appear to protect against MI or stroke.

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