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PNAS:Avastin和Sutent促进了肿瘤干细胞生长

2012/02/01 来源:生物探索
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一项在小鼠中开展的新研究发现,用于治疗乳腺癌的两种药物阿瓦斯汀(Avastin) 和舒癌特(Sutent)会促进肿瘤干细胞的生长。该研究研究也许可以解释为什么以阿瓦斯汀治疗的病人存在复发的风险、以及这些药物尽管最开始减缓了肿瘤的生长但最终无益于提高总体存活率的原因。

一项在小鼠中开展的研究表明,两种抗乳腺癌的药物阿瓦斯汀(Avastin) 和舒癌特(Sutent)可能会无意中促进癌症的生长。研究发现,这两种被设计用于减少向肿瘤供血的药物促进了肿瘤干细胞的生长,潜在地刺激了癌症的扩散。该项发表在PNAS上的研究也许可以解释为什么以阿瓦斯汀治疗的病人存在复发的风险、以及这些药物尽管最开始减缓了肿瘤的生长但最终无益于提高总体存活率的原因。

研究发现阿瓦斯汀(Avastin) 和舒癌特(Sutent)会促进肿瘤干细胞的生长

在这项研究中,来自密西根大学的科学家使用阿瓦斯汀和舒癌特(化学名分别为贝伐单抗和舒尼替尼)治疗患有乳腺癌的小鼠。病人存在患有乳腺癌的小鼠。病ea,病ea,ea,病d细。病ea,病ea,ea,ea,,ea,,i> 掛㗀终无)可能产er;2d9降低氧md="ren" 研氧浓度囊刺表在 囊痜这魘在阿瓦斯汀&nb "> 体人洘段22b”他道22b133be19c癌鼠。病目前为国s获准的生长。该研究砿e的还未纳入国国sren改靿皕验(NHS)國国)家n改靸=免疫些=医这其总䍯">面证据不足md="2011年2月建议反n"的 忂筘在 面药物尜在地刂ea,,i促进是讜其怂该研穟期段的荛是效22b激交些均的风险NEngland Journal of files/9/及dat独立n"1200癌珊1900癌l&w=蛜手p前研 忂 data-cmd=便生p)无22b激都s初期药物尜在地md=手p前的小鼠。病亠)l&w=活期.com/uplo况目前还未知22b133be19c癌

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