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Cell Stem Cell:新鲜血液中巨噬细胞可重新激活衰老老鼠干细胞

2012/01/17 来源:生物探索
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一项研究发现,他们向髓鞘损伤的衰老老鼠体内注入年轻老鼠的新鲜血液,新鲜血液重新激活了衰老老鼠的干细胞,从而促进髓鞘质的生成。研究结果发表在《cell stem cell》杂志上。

一项研究发现,向髓鞘损伤的衰老老鼠体内注入年轻老鼠的新鲜血液,新鲜血液重新激活了衰老老鼠的干细胞,从而促进髓鞘质的生成。研究结果发表在Cell Stem Cell杂志上。

随着多发性硬化症的发生,神经细胞会失去与髓鞘的电隔绝能力。当然干细胞可以产生新的髓鞘质生成细胞,但是随着细胞的衰老,这个过程渐渐失去功效。

剑桥大学的Julia Ruckh和他同事找到一种方法,可以重新激活这些渐渐失去功效的衰老细胞。他们向髓鞘损伤的衰老老鼠体内注入年轻老鼠的新鲜血液,新鲜血液重新激活了衰老老鼠的干细胞,从而促进髓鞘质的生成。

年轻老鼠的白血细胞也称为巨噬细胞聚集在髓鞘损伤处,巨噬细胞可以吞噬和摧毁病原体和残留物,包括损伤的髓鞘。小组成员哈佛大学的Amy Wagers说, 我们知道这些损伤的髓鞘会抑制髓鞘质的再生过程,所以清除残留物很重要。

布里斯托大学的Neil Scolding说,相比把捐献者的干细胞移植到患者体内来治疗多发性硬化症,重新激活衰老的干细胞这个方法更实际。Neil Scolding 没有参加这项研究。


Rejuvenation of Regeneration in the Aging Central Nervous System

Julia M. Ruckh, Jing-Wei Zhao, Jennifer L. Shadrach, Peter van Wijngaarden, Tata Nageswara Rao, Amy J. Wagers, Robin J.M. FranklinSee Affiliations

Remyelination is a regenerative process in the central nervous system (CNS) that produces new myelin sheaths from adult stem cells. The decline in remyelination that occurs with advancing age poses a significant barrier to therapy in the CNS, particularly for long-term demyelinating diseases such as multiple sclerosis (MS). Here we show that remyelination of experimentally induced demyelination is enhanced in old mice exposed to a youthful systemic milieu through heterochronic parabiosis. Restored remyelination in old animals involves recruitment to the repairing lesions of blood-derived monocytes from the young parabiotic partner, and preventing this recruitment partially inhibits rejuvenation of remyelination. These data suggest that enhanced remyelinating activity requires both youthful monocytes and other factors, and that remyelination-enhancing therapies targeting endogenous cells can be effective throughout life.

文献链接:http://www.cell.com/cell-stem-cell/retrieve/pii/S1934590911005807

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