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Eur Heart J:缺乏锻炼是心脏病发作的普遍危险因素

2012/01/15 来源:生物谷
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1月11日,Euro Heart J杂志在线刊登的的一项最新研究分析再次证实,缺乏锻炼是一个普遍的心血管危险因素。体力活动仍旧是全球最被忽视的单纯治疗性干预手段,终生坚持体育锻炼是最简单、最便宜和最有效的远离冠心病措施。

1月11日,Euro Heart J杂志在线刊登的的一项最新研究分析"Physical activity levels, ownership of goods promoting sedentary behaviour and risk of myocardial infarction: results of the INTERHEART study"再次证实,缺乏锻炼是一个普遍的心血管危险因素。业余时间的体力活动和轻到中度的职业性体力活动,但不是重体力劳作,与心血管危险降低有关,而在所有的经济区域中,拥有汽车和电视机则与心肌梗死危险升高有关。

在INTERHEART研究中,研究者对10043例首次发生心肌梗死的病例和14217名既往未报告心绞痛或身体残疾的对照人群进行了病例对照研究,使用问卷调查受试者的工作和业余时间的体力活动情况。该研究的受试者来自亚洲、欧洲、中东、非洲、澳大利亚和北美及南美。

与久坐受试者相比,工作中有轻或重度体力活动的人群心肌梗死危险较低,而重体力活动的人群则不是这样(轻:比值比为0.78;中:比值比为0.89;重:比值比为1.02)。轻度锻炼及中度锻炼或大运动量锻炼有保护作用。体力活动的作用在低收入、中等收入和高收入国家中都一致。

拥有汽车和电视机的受试者与没有这两种物品的受试者心肌梗死危险较高。显然,汽车和电视机增加了人们久坐的时间。而即使很小型的持续日常锻炼也是有益的。只要活动就比不活动好。

事实上,此项分析同时也显示出不同经济水平的国家体力活动水平有巨大差异,低收入国家有70%受试者在闲暇时间不活动,而较高收入国家约为40%。

同期发表的评论文章指出,体力活动仍旧是全球最被忽视的单纯治疗性干预手段,终生坚持体育锻炼是最简单、最便宜和最有效的远离冠心病措施。这项研究给了医生一项艰巨的任务,即将此证据转化为有效的预防工作。

 

Physical activity levels, ownership of goods promoting sedentary behaviour and risk of myocardial infarction: results of the INTERHEART study

Claes Held, Romaina Iqbal, Scott A. Lear, Annika Rosengren, Shofiqul Islam, James Mathew and Salim Yusuf

Aims: To evaluate the association between occupational and leisure-time physical activity (PA), ownership of goods promoting sedentary behaviour, and the risk of myocardial infarction (MI) in different socio-economic populations of the world. Studies in developed countries have found low PA as a risk factor for cardiovascular disease; however, the protective effect of occupational PA is less certain. Moreover, ownership of goods promoting sedentary behaviour may be associated with an increased risk.

Methods: In INTERHEART, a case–control study of 10 043 cases of first MI and 14 217 controls who did not report previous angina or physical disability completed a questionnaire on work and leisure-time PA.

Results: Subjects whose occupation involved either light [multivariable-adjusted odds ratio (OR) 0.78, confidence interval (CI) 0.71–0.86] or moderate (OR 0.89, CI 0.80–0.99) PA were at a lower risk of MI, whereas those who did heavy physical labour were not (OR 1.02, CI 0.88–1.19), compared with sedentary subjects. Mild exercise (OR 0.87, CI 0.81–0.93) as well as moderate or strenuous exercise (OR 0.76, CI 0.69–0.82) was protective. The effect of PA was observed across countries with low, middle, and high income. Subjects who owned both a car and a television (TV) (multivariable-adjusted OR 1.27, CI 1.05–1.54) were at higher risk of MI compared with those who owned neither.

Conclusion: Leisure-time PA and mild-to-moderate occupational PA, but not heavy physical labour, were associated with a reduced risk, while ownership of a car and TV was associated with an increased risk of MI across all economic regions.

文献链接:http://eurheartj.oxfordjournals.org/content/early/2012/01/03/eurheartj.ehr432.full

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