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Nat Neuro:增强PKA与ERK之间反应的学习方案可增强长效记忆

2012/01/11 来源:生物谷
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近日,国际著名杂志《自然-神经学》NATURE NEUROSCIENCE在线刊登了美国研究人员的最新研究成果,文章中,研究人员运用数学建模的办法使得酶能在训练和学习过程中得到最大限度的激活。

近日,国际著名杂志《NATURE NEUROSCIENCE》在线刊登了美国研究人员的最新研究成果“Computational design of enhanced learning protocols”,文章中,研究人员运用数学建模的办法使得酶能在训练和学习过程中得到最大限度的激活。

教育人士一直都认为,掌握好的学习方法需要培养发散性思维,而非死记硬背。这篇文章除了证明这点外,还认为“适当时机”比之前认为的要更复杂。这项研究证明,将已知分子事件即时考虑在内,设计相应的培养环境是可行的,这为未来针对改进更高等有机体的学习与记忆能力所开展的检验设计研究提供了范本。

先前的研究证实了,蛋白激酶A(PKA)与细胞外信号调节激酶(ERK)的级联对于诱导海兔的长效突触易化(LTF)是所必须的。John Byrne与同事对PKA与ERK之间的级联进行数学建模,并依此而建立起可将PKA与ERK之间反应最大化的训练方案。体外实验证实,这种优化的方案增强了LTF,并且增强了转录因子CREB1的磷酸化水平。行为训练证实,该方案可以提高长效记忆。

该研究的结果说明,使用计算模型来制定特定的训练方案对于提升记忆是可行的。

 

Computational design of enhanced learning protocols

Yili Zhang, Rong-Yu Liu, George A Heberton, Paul Smolen, Douglas A Baxter, Leonard J Cleary & John H Byrne

Learning and memory are influenced by the temporal pattern of training stimuli. However, the mechanisms that determine the effectiveness of a particular training protocol are not well understood. We tested the hypothesis that the efficacy of a protocol is determined in part by interactions among biochemical cascades that underlie learning and memory. Previous findings suggest that the protein kinase A (PKA) and extracellular signal–regulated kinase (ERK) cascades are necessary to induce long-term synaptic facilitation (LTF) in Aplysia, a neuronal correlate of memory. We developed a computational model of the PKA and ERK cascades and used it to identify a training protocol that maximized PKA and ERK interactions. In vitro studies confirmed that the protocol enhanced LTF. Moreover, the protocol enhanced the levels of phosphorylation of the transcription factor CREB1. Behavioral training confirmed that long-term memory also was enhanced by the protocol. These results illustrate the feasibility of using computational models to design training protocols that improve memory.

文献链接:http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.2990.html

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