BJP:新药理学指南阐明多种药物靶点特性
生物谷 · 2016/01/10
2015/2016新型的简明的药理学指南为超过1700多种人类药物靶点提供了一项最有价值且最为独特的特性概览,这对于目前临床治疗或未来治疗性策略的开发将带来非常重要的信息和参数。


2015/2016新型的简明的药理学指南为超过1700多种人类药物靶点提供了一项最有价值且最为独特的特性概览,这对于目前临床治疗或未来治疗性策略的开发将带来非常重要的信息和参数。

这项指南每两年发布一次,而且可以在互联网上免费获取,国际基础药理学与临床药理学联合会的命名委员会会对大量相关的信息进行收集,而该组织是一个志愿、非营利性的药理学团体,其代表着全球药理学家们的利益。

这项准则发表于国际杂志the British Journal of Pharmacology上,研究者Stephen Alexander博士表示,目前更新的准则是最先进的参考指南,其可以指导科学家们寻找并研究大量关键的药理学及治疗性的药物靶点;该指南将定量的药理学数据同大量的受体、离子通道、转运蛋白及酶类家族相结合,从而就可以为任何一名科学家提供新的研究领域来快速获取其所想要的药物靶点的相关数据信息。

目前可以通过该网站(http://www.guidetopharmacology.org/)获取更多关于药物分子靶点的大量信息,同时这些信息也将指导研究人员建立更多遗传学、治疗、分子生物学、免疫学及化学特性的在线数据库,帮助科学家们从事相关的研究工作。

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  • The Concise Guide to PHARMACOLOGY 2015/16: Overview

    The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13347/full. This compilation of the major pharmacological targets is divided into eight areas of focus: G protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The Concise Guide is published in landscape format in order to facilitate comparison of related targets. It is a condensed version of material contemporary to late 2015, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in the previous Guides to Receptors & Channels and the Concise Guide to PHARMACOLOGY 2013/14. It is produced in conjunction with NC-IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR-DB and GRAC and provides a permanent, citable, point-in-time record that will survive database updates.

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